• Our Research

    We aim to learn more about our genome in sequence, conformation, and function.

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    98% of the mammalian genome are non-coding regions, which harbor numerous cis-regulatory elements and facility the spatial organization of the genome. The dynamic of genome organization and cis-regulatory elements contribute to spatiotemporal gene activities that can direct specialized cell types in multi-cellular organisms, which forms the foundation for us to understand the diverse biological processes in different physiological and pathological conditions.

     

    In our lab, we will utilize single-cell multi-omics and functional genomics to examine the mechanisms and functions of epigenetic modifications, 3D genome organization, and non-coding cis-regulatory elements in regulating gene expression, which will be the foundation to further understand gene regulation in cell fate decision, embryo development, and its dysregulation in variety of human diseases.

  • Representative Publications

    For a complete list of publications, click here. (*equal contribution. #co-correspondence)

    1. Hao Tian, Pengfei Luan, Yaping Liu, Guoqiang Li#, Tet-mediated DNA methylation dynamics affect chromosome organization, Nucleic Acids Research, 52(2024): 3654-3666.
    2. Guoqiang Li*, Yaping Liu*, Yanxiao Zhang, Naoki Kubo, Miao Yu, Rongxin Fang, Manolis Kellis and Bing Ren. “Joint profiling of DNA methylation and chromatin architecture in single cells.” Nature Methods, 16 (2019): 991–993.
    3. Xiaocui Xu*, Guoqiang Li*, Congru Li*, Jing Zhang*, Qiang Wang*, David K Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, Zhenhua Wang, Bao Ju, Weimin Ci, Xuemei Lu, Daqi YuQian-fei Wang, Neelakanteswar Aluru, Paola Oliveri, Yong E Zhang, Mark Q Martindale and Jiang Liu. “Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis.” National Science Review, nwz064 (2019)
    4. Congru Li*, Yang Yu*, Yong Fan*, Guoqiang Li*, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao and Jiang Liu. “DNA methylation reprogramming of functional elements during mammalian embryonic development.” Cell Discovery 4, no. 28 (2018).
    5. Guoqiang Li*, Yang Yu*, Yong Fan*, Congru Li*, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao and Jiang Liu. “Genome-wide abnormal DNA methylome of human blastocyst in assisted reproductive technology.” Journal of Genetics and Genomics 44 (2017): 475-481.
    6. Guoqiang Li*, Weimin Ci*, Subhradip Karmakar*, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu and Kevin P. White. “SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.” Cancer Cell 25, no. 4 (2014): 455-468.

  • Current Members

    We’re continuously growing and always looking for motivated students and postdocs to join our team. Please get in touch with the PI if you want to join us.

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    Guoqiang Li 李国强

    PI

    Ph.D. in Genomics, University of Chinese Academy of Sciences
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    Huihui Du 杜慧慧

    Lab Administrator

    M.S. in Management, Renmin University

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    Yuhe Pei 裴玉禾

    Graduate Student
    B.S. in Biology, Wuhan University
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    Zhuoyu Zhang 张卓宇

    Graduate Student
    B.S. in Biology, Shandong University
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    Pengfei Luan 栾鹏飞

    Visiting Graduate Student

    M.S. in Genetics, Ningxia Medical University

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    Lai Yilin 赖依林

    Undergraduate Student

    Peking University

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    Zongwei Zhang 张宗玮

    Graduate Student
    B.S. in Biology, Harbin Institute of Technology
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    Mingrui Tan 谭明瑞

    Graduate Student
    B.S. in Biology, Huazhong University of Science and Technology
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    Yucen Wang 王芋岑

    Graduate Student
    B.S. in Biology, Huazhong University of Science and Technology
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    Lianqi He 贺连琦

    Graduate Student
    B.S. in Biology, Shandong University
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    Zilin Zhu 朱姿琳

    Graduate Student
    B.S. in Biology, Sichuan University
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    Qingliang Liang 梁清亮

    Research Assistant

    B.S. in Biology, Beijing Normal University

    Alumni

    Hao Tian (田昊), Postdoc, 2021-2024

    Wenbo Bai (白文波), Research Assistant, 2021-2023

    Yunning Yuan (袁蕴宁), Undergraduate Summer Intern, 2022, 2023

    Lin Xi (席琳), Undergraduate Intern, 2023

  • Contact us

    Email:liguoqiang@pku.edu.cn

    Phone: 010-62757927

    Address: Biomedical Pioneering Innovation Center, Peking University, Beijing, China, 100871